Cov metabolites ntawm THC muaj zog tshaj THC

Cov kws tshawb fawb tau tshawb pom tias thawj cov metabolite ntawm THC tseem muaj zog raws li cov ntaub ntawv los ntawm cov qauv nas. Cov ntaub ntawv tshawb fawb tshiab qhia tias lub ntsiab THC metabolite lingering nyob rau hauv cov zis thiab ntshav kuj tseem yuav ua haujlwm thiab ua haujlwm zoo li THC, yog tias tsis yog ntau dua. Qhov kev tshawb nrhiav tshiab no ua rau muaj lus nug ntau dua li nws teb. Raws li kev tshawb fawb tsis ntev los no tau luam tawm hauv Phau Ntawv Xov Xwm ntawm Pharmacology thiab Kev Tshawb Fawb Kev Kho Mob, psychoactive metabolite ntawm THC, 11-hydroxy-THC (11-OH-THC), muaj sib npaug lossis ntau dua kev puas siab puas ntsws ntau dua THC (Delta-9 THC).

Txoj kev tshawb no, lub npe hu ua "Intoxication Equivalence ntawm 11-Hydroxy-Delta-9-THC (11-OH-THC) txheeb ze rau Delta-9-THC," qhia tau hais tias THC metabolites khaws cov haujlwm li cas. Nws paub zoo tias THC tawg thiab tsim cov tshuaj lom neeg tshiab thaum nws decarboxylates thiab ua rau tib neeg lub cev. "Nyob rau hauv txoj kev tshawb no, peb tau txiav txim siab tias cov metabolite tseem ceeb ntawm THC, 11-OH-THC, pom muaj kev sib npaug lossis ntau dua li THC hauv cov qauv nas cannabinoid thaum tswj ncaj qha, txawm tias xav txog qhov sib txawv hauv kev tswj hwm, kev sib deev, pharmacokinetics, thiab pharmacodynamics," txoj kev tshawb fawb hais. "Cov ntaub ntawv no muab kev nkag siab tseem ceeb rau kev ua haujlwm lom neeg ntawm THC metabolites, qhia txog kev tshawb fawb cannabinoid yav tom ntej, thiab ua qauv li cas THC noj thiab cov metabolism cuam tshuam rau tib neeg siv cannabis."

Qhov kev tshawb fawb no tau ua los ntawm ib pab neeg los ntawm Saskatchewan, Canada, suav nrog Ayat Zagzoog, Kenzie Halter, Alayna M. Jones, Nicole Bannatyne, Joshua Cline, Alexis Wilcox, Anna-Maria Smolyakova, thiab Robert B. Laprairie. Hauv kev sim, cov kws tshawb fawb tau txhaj cov txiv neej nas nrog 11-hydroxy-THC thiab tau soj ntsuam thiab kawm txog cov teebmeem ntawm THC metabolite no piv rau nws niam nws txiv, Delta-9 THC.

Cov kws tshawb fawb tau sau tseg ntxiv tias: "Cov ntaub ntawv no qhia tau tias hauv qhov kev sim tw tw rau qhov kev hnov ​​​​mob, kev ua ntawm 11-OH-THC yog 153% ntawm THC, thiab hauv kev kuaj mob catalepsy, qhov kev ua ntawm 11-OH-THC yog 78% ntawm THC. Yog li ntawd, txawm xav txog qhov sib txawv ntawm pharmacokinetic, 11-OH-paj yeeb yam sib txawv txawm tias nws cov txiaj ntsig zoo heev. THC."

Yog li, txoj kev tshawb fawb qhia tias THC metabolite 11-OH-THC tuaj yeem ua lub luag haujlwm tseem ceeb hauv kev ua haujlwm lom neeg ntawm cannabis. Nkag siab txog nws txoj haujlwm thaum tswj hwm ncaj qha yuav pab piav qhia txog kev tshawb fawb tsiaj thiab tib neeg yav tom ntej. Daim ntawv tshaj tawm hais tias 11-OH-THC yog ib qho ntawm ob lub hauv paus metabolites tsim tom qab noj cannabis, lwm qhov yog 11-lossis-9-carboxy-THC, uas tsis yog kev puas siab puas ntsws tab sis tuaj yeem nyob hauv cov ntshav lossis zis ntev.

Raws li US Lub Chaw Tiv Thaiv thiab Tiv Thaiv Kab Mob (CDC), thaum ntxov li xyoo 1980, kev kuaj zis feem ntau tsom rau 11-nor-delta-9-THC-9-carboxylic acid (9-carboxy-THC), metabolite ntawm Delta-9-THC, uas yog cov khoom xyaw tseem ceeb hauv cannabis.

Daim ntawv tshaj tawm qhia tau hais tias txawm hais tias kev haus luam yeeb cannabis feem ntau ua rau muaj kev cuam tshuam sai dua li kev siv cov cannabis edibles, tus nqi ntawm 11-OH-THC tsim los ntawm kev noj haus yog ntau dua li ntawm kev haus luam yeeb cannabis paj. Daim ntawv tshaj tawm qhia tias qhov no yog ib qho laj thawj vim li cas cov khoom noj cannabis-infused tuaj yeem dhau los ua kev puas siab puas ntsws ntau dua thiab ua rau muaj kev ntxhov siab rau qhov tsis tau npaj.

THC Metabolites thiab Kev Ntsuas Tshuaj

Cov ntaub ntawv pov thawj qhia tias cannabis cuam tshuam rau cov neeg siv sib txawv nyob ntawm txoj kev tswj hwm. Ib txoj kev tshawb fawb xyoo 2021 tau tshaj tawm nyob rau hauv Phau Tsom Faj Tseem Ceeb tau qhia tias qhov cuam tshuam ntawm kev haus cov cannabis noj tau ntau dua li kev haus luam yeeb cannabis vim yog cov metabolism ntawm 11-OH-THC.

"Lub bioavailability ntawm THC los ntawm vaporization yog 10% mus rau 35%," cov kws tshawb fawb tau sau. "Tom qab kev nqus, THC nkag mus rau hauv daim siab, qhov feem ntau ntawm nws raug tshem tawm lossis metabolized rau hauv 11-OH-THC lossis 11-COOH-THC, nrog rau THC ntxiv thiab nws cov metabolites nkag mus rau hauv cov hlab ntsha. Los ntawm kev noj qhov ncauj, qhov bioavailability ntawm THC tsuas yog 4% mus rau 12%. Feem ntau, plasma ib nrab-lub neej ntawm THC nyob rau qee zaus cov neeg siv yog 1 mus rau 3 hnub, thaum nyob rau hauv cov neeg siv ntev, nws tuaj yeem ntev li 5 txog 13 hnub. "

Cov kev tshawb fawb pom tau tias ntev tom qab cov teebmeem kev puas siab puas ntsws ntawm cannabis tau hnav, THC metabolites zoo li 11-OH-THC tuaj yeem nyob hauv cov ntshav thiab zis rau lub sijhawm ntev. Qhov no ua rau muaj kev sib tw rau cov txheej txheem ntawm kev sim seb cov neeg tsav tsheb thiab cov neeg ncaws pob puas muaj kev cuam tshuam los ntawm kev siv cannabis. Piv txwv li, Australian cov kws tshawb fawb tau sim txiav txim siab lub sijhawm lub sijhawm uas cannabis tuaj yeem cuam tshuam kev tsav tsheb. Hauv ib kis, Thomas R. Arkell, Danielle McCartney, thiab Iain S. McGregor los ntawm Lambert Initiative ntawm University of Sydney tau kawm txog qhov cuam tshuam ntawm cannabis rau kev muaj peev xwm tsav tsheb. Pab pawg tau txiav txim siab tias cannabis tsis muaj peev xwm tsav tsheb rau ob peb teev tom qab haus luam yeeb, tab sis cov kev puas tsuaj no xaus ua ntej THC metabolites raug tshem tawm los ntawm cov ntshav, nrog cov metabolites nyob hauv lub cev rau lub lis piam lossis hli.

"Cov neeg mob siv cov khoom uas muaj THC yuav tsum zam kev tsav tsheb thiab lwm yam kev nyab xeeb-rhiab ua haujlwm (xws li, cov tshuab ua haujlwm), tshwj xeeb tshaj yog thaum pib kho mob thiab ob peb teev tom qab txhua koob tshuaj," cov kws sau ntawv sau. "Txawm hais tias cov neeg mob tsis hnov ​​​​mob, lawv tseem tuaj yeem kuaj qhov zoo rau THC. Tsis tas li ntawd, cov neeg mob cannabis kho mob tam sim no tsis raug zam los ntawm kev sim tshuaj mobile ntawm txoj kev thiab kev rau txim raug cai."

Qhov kev tshawb fawb tshiab no ntawm 11-OH-THC qhia tias yuav tsum muaj kev tshawb fawb ntxiv kom nkag siab tob npaum li cas THC metabolites cuam tshuam rau tib neeg lub cev. Tsuas yog los ntawm kev siv zog tas mus li peb tuaj yeem nthuav tawm cov lus zais ntawm cov ntsiab lus tshwj xeeb no.